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Source: NSF Disability and Rehabilitation Engineering


Title: SEPCORPS Model - SEParating CORtical and SPinal -level motor control responses using transcranial direct current stimulation and transcutaneous electrical stimulation
Filip Stefanovic - PI
Budget: $291,062 USD (Award ID: 2130651)
We are developing the first corticospinal model in volitional motor control for use in clinical neurorehabilitation. To accomplish this, we use fMRI to map the functional topologies of volitional neuromuscular control to identify the cortical “hot spots” associated with movement execution. When identified, we stimulate these areas with non-invasive brain stimulation and construct brain input-output response curves. Through experimentation, we also apply transcutaneous electrical stimulation and measure spinal level commands and response. These data are then used as part of a novel grey-box model representing corticospinal systems that emulate brain-muscle pathways based on neuroanatomical structures. This model is then developed to optimize non-invasive neurorehabilitation protocols, and further develop our understanding of neuromuscular control in healthy and paretic individuals.

Source: Clinical and Translational Science Institute (CTSI) via the NIH CTSA UL1

Title: Assessing the Efficacy of Alterations in Subcortical-Cortical Functional Connectivity from Transcranial Direct Current Stimulation in Older Children after Mild Traumatic Brain Injury
Filip Stefanovic - Co-I
Budget: $54,380 USD (Award ID: PS-SALEEM under UL1TR001412)

In this study, we aim to first determine the efficacy of tDCS in promoting recovery in older children (age range 10 to 17 years) with persistent symptoms of mTBI, and to test the use of neural correlates in providing insight into functional change and recovery. If the aims of this proposal are achieved, the role of tDCS in promoting neuroplasticity and recovery in children with mTBI will be established for the first time. Further, positive rs-fMRI outcomes will lay the basis for exploring neurophysiological response to treatment and recovery in even younger children with mTBI. This study’s results will open up future possibilities for restoring function in children at a single-subject level.

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